Selected biomarkers associated with atherosclerosis and bone metabolism

Czech version

Authors: Katarína Demková; Ivan Tkáč
Authors‘ workplace: IV. interná klinika LF UPJŠ a UNLP, Košice
Published in: AtheroRev 2020; 5(3): 168-172
Category: Reviews

Overview

Atherosclerosis is characterized by persistent inflammation of the vascular wall and is considered to be a major cause contributing to the development of cardiovascular disease, which is the leading cause of death worldwide. Due to the prevalence of atherosclerosis and its complications, the need for early and, if possible, non-invasive diagnosis is increasing in order to prevent the development of fatal or disabling complications of atherosclerosis. Imaging methods as well as clinical examinations are used for the detection of atherosclerotic plaques, which capture up to hemodynamically significant plaques. Better prevention of atherosclerosis requires the search for high-risk individuals in early stages. Inflammation manifests itself throughout the course of atherogenesis, i.e. also in the stage of subclinical atherosclerosis, when it is possible to determine the concentration of inflammatory biomarkers in the blood. Biomarkers are of interest for the simplicity of determination in plasma or serum and the possibility of their use for diagnostic, prognostic and therapeutic purposes. Positive correlations with atherosclerosis and its complications have been demonstrated in biomarkers associated with bone metabolism such as fibroblast growth factor 23, osteocalcin, osteoglycin, osteopontin or osteoprotegerin.

Keywords:

osteoprotegerin – osteoglycin – fibroblast growth factor 23 – osteocalcin – osteopontin

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