Impact of SGLT2 inhibitors and real clinical practice

Czech version

Authors: Branislav Vohnout ^1,2,3; Jana Lisičanová ³; Andrea Havranová ⁴
Authors‘ workplace: Ústav výživy, Fakulta ošetrovateľstva a zdravotníckych odborných štúdií a Koordinačné centrum pre familiárne hyperlipoproteinémie, Slovenská zdravotnícka univerzita v Bratislave ¹; Ústav epidemiológie LF UK, Bratislava ²; Diabetologická ambulancia Diabeda, Bratislava ³; Ústav klinického a translačného výskumu, Biomedicínske centrum Slovenskej akadémie vied, Bratislava ⁴
Published in: AtheroRev 2020; 5(3): 158-161
Category: Reviews

Overview

Atherosclerotic cardiovascular disease is the primary cause of death in diabetes patients. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a newly identified class of drugs that in addition to glucose lowering effect have shown cardiovascular protective effects and even reduction of all-cause mortality. RWE studies that reflect common clinical practice have confirmed the effect from clinical trials. Possible mechanism of the cardioprotective effect are discussed.

Keywords:

cardiovascular disease – real-world evidence – SGLT2 inhibitor

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