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The role of bilirubin in diabetes, metabolic syndrome and cardiovascular diseases

Czech version

Authors: Libor Vítek
Authors‘ workplace: IV. interní klinika a Ústav lékařské biochemie a laboratorní diagnostiky 1. LF UK a VFN v Praze
Published in: AtheroRev 2019; 4(2): 82-85
Category: Reviews

Overview

For long time bilirubin was considered only an ominous sign of liver diseases. However, based on recent research, bilirubin is nowadays known as a potent antioxidant molecule, possessing additional biological activities. Bilirubin is a powerful anti-inflammatory compound, modulates number of intracelullar signaling pathways, affects protein phosphorylation. All these mechanisms may account for the protective effects of bilirubin against development of many civilization diseases. Its salutary effects on atherogenesis are generally accepted, but its serum concentrations have negative relationship also to risk of diabetes, obesity, arterial hypertension, metabolic syndrome or non-alcoholic steatohepatitis. Based on clinical studies, it is clear now that each micromolar increase of serum bilirubin concentrations is associated with significant health benefits. Subjects with mildly elevated serum bilirubin concentrations, such in Gilbert syndrome (benign hyperbilirubinemia), have much lower risk of these diseases, whereas those with low serum bilirubin levels are at much higher risk.

Keywords:

diabetes – antioxidant – bilirubin – Gilbert syndrome – cardiovascular diseases – risk factor

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Labels
Angiology Diabetology Internal medicine Cardiology General practitioner for adults
Diabetes mellitus, kardiovaskulární onemocnění a poruchy metabolizmu lipidů
New hypolipidemic agents in the treatment of diabetic dyslipidemia
Hypertension and diabetes – malignant cardiometabolic combination
Effect of novel anti-diabetic medication on cardiovascular risk
Hypolipidemic treatment and microvascular complications of diabetes
ODYSSEY OUTCOMES Study: other clinical relevant analyses
HDL-C and stratification of individual risk
Current medical literature: exploration of facts
22. kongres o ateroskleróze
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