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Hypolipidemic treatment and microvascular complications of diabetes

Czech version

Authors: Branislav Vohnout 1,2,3,5;  Jana Lisičanová 3;  Andrea Havranová 4
Authors‘ workplace: Ústav výživy, Fakulta ošetrovateľstva a zdravotníckych odborných štúdií, SZU v Bratislave 1;  Ústav epidemiológie LF UK, Bratislava 2;  Ambulancia diabetológie a porúch látkovej premeny a výživa, Diabeda s. r. o., Bratislava 3;  Ústav klinického a translačného výskumu – Biomedicínske centrum SAV, Bratislava 4;  Koordinačné centrum pre familiárne hyperlipoproteinémie, SZU v Bratislave 5
Published in: AtheroRev 2019; 4(2): 95-99
Category: Reviews

Overview

Diabetes mellitus (DM) is associated with an increased risk of developing micro- and macrovascular complications. One of the factors that may be involved in the onset and progression of microvascular impairment is dyslipidemia. While the effect of dyslipidemia and its treatment on cardiovascular risk in patients is well known, the effect of hypolipidemic treatment on microvascular complications is not so clear. Although some studies suggest a possible effect of statins on some microvascular complications, these data are often contradictory, and the positive effect of statins on microvascular complications has not been demonstrated. On the other hand, the results of clinical trials show the promising effect of fibrates on the progression of microvascular complications of diabetes. Within the FIELD and ACCORD studies, treatment with fenofibrate led to a slowdown in the progression of diabetic retinopathy, and in the FIELD study retinal laser treatment was significantly reduced and the number of non-traumatic lower limb amputations decreased. This positive effect is probably due not only to the hypolipidemic but also to other pleiotropic effects of such treatment. The paper presents an overview of the effects of hypolipidemic treatment with respect to influencing the individual microvascular complications of diabetes.

Keywords:

diabetes – fenofibrate – microvascular complications

Sources
  1. Manuel DG, Schultz SE. Health-related quality of life and health-adjusted life expectancy of people with diabetes in Ontario, Canada, 1996–1997. Diabetes Care 2004; 27(2): 407–414.
  2. Wandell PE. Quality of life of patients with diabetes mellitus. An overview of research in primary health care in the Nordic countries. Scand J Prim Health Care 2005; 23(2):68–74. Dostupné z DOI: <http://dx.doi.org/10.1080/02813430510015296>.
  3. [UK Prospective Diabetes Study (UKPDS) Group]. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998; 352(9131): 837–853. Erratum in Lancet 1999; 354(9178): 602.
  4. Nathan DM, Genuth S, Lachin J et al. [Diabetes Control and Complications Trial Research Group]. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329(14): 977–986. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJM199309303291401>.
  5. Piepoli MF, Hoes AW, Agewall S et al. [Authors/Task Force Members]. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Atherosclerosis 2016; 252: 207–274. Dostupné z DOI: <http://dx.doi.org/10.1016/j.atherosclerosis.2016.05.037>.
  6. Valensi P, Picard S. Lipids, lipid-lowering therapy and diabetes complications. Diabetes Metab 2011; 37(1):15–24. Dostupné z DOI: <http://dx.doi.org/10.1016/j.diabet.2010.10.001>.
  7. Karásek D, Vaverková H. Diabetická dyslipidemie a mikrovaskulární komplikace diabetu. Vnitř Lék 2018; 64(1): 17–24.
  8. Zoppini G, Negri C, Stoico V et al. Triglyceride-high-density lipoprotein cholesterol is associated with microvascular complications in type 2 diabetes mellitus. Metabolism 2012; 61(1): 22–29. Dostupné z DOI: <http://dx.doi.org/10.1016/j.metabol.2011.05.004>.
  9. Morton J, Zoungas S, Li Q et al. Low HDL cholesterol and the risk of diabetic nephropathy and retinopathy: results of the ADVANCE study. Diabetes Care 2012; 35(11): 2201–2206. Dostupné z DOI: <http://dx.doi.org/10.2337/dc12–0306>.
  10. Sacks FM, Hermans MP, Fioretto P et al. Association between plasma triglycerides and high-density lipoprotein cholesterol and microvascular kidney disease and retinopathy in type 2 diabetes mellitus: a global case-control study in 13 countries. Circulation 2014; 129(9): 999–1008. Dostupné z DOI: <http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002529>.
  11. Hadjadj S, Duly-Bouhanick B, Bekherraz A et al. Serum triglycerides are a predictive factor for the development and the progression of renal and retinal complications in patients with type 1 diabetes. Diabetes Metab 2004; 30(1): 43–51.
  12. Lyons TJ, Jenkins AJ, Zheng D et al. Diabetic retinopathy and serum lipoprotein subclasses in the DCCT/EDIC cohort. Invest Ophthalmol Vis Sci 2004; 45(3): 910–918.
  13. Bonnet F, Cooper ME. Potential influence of lipids in diabetic nephropathy: insights from experimental data and clinical studies. Diabetes Metab 2000; 26(4): 254–264.
  14. Gall MA, Hougaard P, Borch-Johnsen K et al. Risk factors for development of incipient and overt diabetic nephropathy in patients with non-insulin dependent diabetes mellitus: prospective, observational study. BMJ 1997; 314(7083): 783–788. Dostupné z DOI: <http://dx.doi.org/10.1136/bmj.314.7083.783>.
  15. Elliott J, Tesfaye S, Chaturvedi N et al. Large-fiber dysfunction in diabetic peripheral neuropathy is predicted by cardiovascular risk factors. Diabetes Care 2009; 32(10): 1896–1900. Dostupné z DOI: <http://dx.doi.org/10.2337/dc09–0554>.
  16. Van Acker K, Bouhassira D, De Bacquer D et al. Prevalence and impact on quality of life of peripheral neuropathy with or without neuropathic pain in type 1 and type 2 diabetic patients attending hospital outpatients clinics. Diabetes Metab 2009; 35(3): 206–213. Dostupné z DOI: <http://dx.doi.org/10.1016/j.diabet.2008.11.004>.
  17. Collins R, Armitage J, Parish S et al. [Heart Protection Study Collaborative Group]. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet 2003; 361(9374): 2005–2016.
  18. Colhoun HM, Betteridge DJ, Durrington PN et al. [CARDS investigators]. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet 2004; 364(9435): 685–696. Dostupné z DOI: <http://dx.doi.org/10.1016/S0140–6736(04)16895–5>.
  19. Aguiar C, Alegria E, Bonadonna RC et al. A review of the evidence on reducing macrovascular risk in patients with atherogenic dyslipidaemia: A report from an expert consensus meeting on the role of fenofibrate-statin combination therapy. Atheroscler Suppl 2015; 19: 1–12. Dostupné z DOI: <http://dx.doi.org/10.1016/S1567–5688(15)30001–5>.
  20. Ferrari R, Aguiar C, Alegria E et al. Current practice in identifying and treating cardiovascular risk, with a focus on residual risk associated with atherogenic dyslipidaemia. Eur Heart J Suppl 2016; 18(Suppl C): C2-C12. Dostupné z DOI: <http://dx.doi.org/10.1093/eurheartj/suw009>.
  21. Nielsen SF, Nordestgaard BG. Statin use before diabetes diagnosis and risk of microvascular disease: a nationwide study. Lancet Diabetes Endocrinol 2014; 2(11): 894–900. Dostupné z DOI: <http://dx.doi.org/10.1016/S2213–8587(14)70173–1>.
  22. Donaldson M, Dodson PM. Medical treatment of diabetic retinopathy. Eye 2003; 17(5): 550–562. Dostupné z DOI: <http://dx.doi.org/10.1038/sj.eye.6700586>.
  23. Collins R, Armitage J, Parish S et al. [Heart Protection Study Collaborative Group]. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet 2003; 361(9374): 2005–2016.
  24. Keech AC, Mitchell P, Summanen PA et al. Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial. Lancet 2007; 370(9600): 1687–1697. Dostupné z DOI: <http://dx.doi.org/10.1016/S0140–6736(07)61607–9>.
  25. Chew EY, Ambrosius WT, Davis MD et al. [ACCORD Study Group; ACCORD Eye Study Group]. Effects of medical therapies on retinopathy progression in type 2 diabetes. New Engl J Med 2010; 363(3): 233–244. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1001288>. Erratum in N Engl J Med 2011; 364(2): 190. N Engl J Med 2012; 367(25): 2458.
  26. Sharma N, Ooi JL, Ong J et al. The use of fenofibrate in the management of patients with diabetic retinopathy: an evidence-based review. Aust Fam Physician 2015; 44(6): 367–370.
  27. Colhoun HM, Betteridge DJ, Durrington PN et al. Effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes: an analysis from the Collaborative Atorvastatin Diabetes Study (CARDS). Am J Kidney Dis 2009; 54(5): 810–819. Dostupné z DOI: <http://dx.doi.org/10.1053/j.ajkd.2009.03.022.
  28. Shen X, Zhang Z, Zhang X et al. Efficacy of statins in patients with diabetic nephropathy: a meta-analysis of randomized controlled trials. Lipids Health Dis 2016; 15(1): 179. Dostupné z DOI: <http://dx.doi.org/10.1186/s12944–016–0350–0>.
  29. Qin X, Dong H, Fang K et al. The effect of statins on renal outcomes in patients with diabetic kidney disease: A systematic review and meta-analysis. Diabetes Metab Res Rev 2017; 33(6). Dostupné z DOI: <http://dx.doi.org/10.1002/dmrr.2901>.
  30. Keech A, Simes RJ, Barter P et al. The FIELD study investigators. Effect of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 2005; 366(9500): 1849–1861. Dostupné z DOI: <http://dx.doi.org/10.1016/S0140–6736(05)67667–2>. Erratum in Correction to the FIELD study report. [Lancet. 2006]. Lancet 2006; 368(9545): 1420.
  31. Ginsberg HN, Elam MB, Lovato LC et al. [ACCORD Study Group]. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med 2010; 362(17): 1563–1574. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1001282>. Erratum in N Engl J Med 2010; 362(18): 1748.
  32. Jun M, Zhu B, Tonelli M et al. Effects of fibrates in kidney disease: a systematic review and meta-analysis. J Am Coll Cardiol 2012; 60(20): 2061–2071. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jacc.2012.07.049>.
  33. Davis TM, Yeap BB, Davis WA et al. Lipid-lowering therapy and peripheral sensory neuropathy in type 2 diabetes: the Fremantle Diabetes Study. Diabetologia 2008; 51(4): 562–566. Dostupné z DOI: <http://dx.doi.org/10.1007/s00125–007–0919–2>.
  34. Rajamani K, Colman PG, Li LP et al. [FIELD study investigators]. Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial. Lancet 2009; 373(9677): 1780–1788. Dostupné z DOI: <http://dx.doi.org/10.1016/S0140–6736(09)60698-X>.
  35. Hermans MP. Prevention of microvascular diabetic complications by fenofibrate: lessons from FIELD and ACCORD. Diab Vasc Dis Res 2011; 8(3):180–189. Dostupné z DOI: <http://dx.doi.org/10.1177/1479164111407783>.
Labels
Angiology Diabetology Internal medicine Cardiology General practitioner for adults
Diabetes mellitus, kardiovaskulární onemocnění a poruchy metabolizmu lipidů
New hypolipidemic agents in the treatment of diabetic dyslipidemia
The role of bilirubin in diabetes, metabolic syndrome and cardiovascular diseases
Hypertension and diabetes – malignant cardiometabolic combination
Effect of novel anti-diabetic medication on cardiovascular risk
ODYSSEY OUTCOMES Study: other clinical relevant analyses
HDL-C and stratification of individual risk
Current medical literature: exploration of facts
22. kongres o ateroskleróze
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