Secondary and adverse effects of antihypertensive drugs
Authors:
Jiří Vítovec 1; Jindřich Špinar 2
Authors‘ workplace:
I. interní kardioangiologická klinika LF MU a FN u sv. Anny v Brně
1; Interní kardiologická klinika LF MU a FN Brno, pracoviště Bohunice
2
Published in:
AtheroRev 2018; 3(1): 15-17
Category:
Reviews
Overview
It includes a brief overview of secondary and unwanted effects of basic antihypertensive drugs which may influence patients toward discontinuation of medication with the ensuing danger of complications associated with uncontrolled blood pressure. The greatest amount of possible side effects of the basic antihypertensive drugs is described for diuretics and beta-blockers. We not only describe these side effects, but we also specify which class of drugs carries the least side effects and the lowest risk of discontinuation by patients.
Key words:
beta-blockers, calcium channel blockers, diuretics, ACE-inhibitors, adverse effects, sartans
Received:
10. 12. 2017
Accepted:
15. 1. 2018
Sources
1. Evans SJ, Waller PC, S. Davis. Use of proportional reporting ratios (PRRs) for signal generation from spontaneous adverse drug reaction reports. Pharmacoepidemiol Drug Safety 2001; 10(6): 483–486. Dostupné z DOI: <http://dx.doi.org/10.1002/pds.677>.
2. Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet 2000; 356(9237): 1255–1259. Dostupné z DOI: <http://dx.doi.org/10.1016/S0140–6736(00)02799–9>.
3. Husserl FE, Messerli FH. Adverse Effects of Antihypertensive Drugs. Drugs 1981; 22(3): 188–210.
4. Petrák O. Negativní metabolické působení antihypertenziv. Je to vůbec klinicky relevantní? AtheroRev 2016; 1(2): 74–79.
5. Deshmukh M, Lee HW, McFarlane SI et al. Antihypertensive medications and their effects on lipid metabolism. Curr Diab Rep 2008; 8(3): 214–220.
6. Špinar J, Ondráčková B. Eplerenon. Remedia 2006; 16(5): 455–462.
7. Bangalore S, Parkar S, Grossman E et al. A meta-analysis of 94,492 patients with hypertension treated with beta blockers to determine the risk of new-onset diabetes mellitus. Am J Cardiol 2007; 100(8): 1254–1262. Dostupné z DOI: <http://dx.doi.org/10.1016/j.amjcard.2007.05.057>.
8. Silvestri A, Galetta P, Cerquetani E et al. Report of erectile dysfunction after therapy with beta-blockers is related to patient knowledge of side effects and is reversed by placebo. Eur Heart J 2003; 24(21): 1928–1932.
9. Šipula J. Blokátory kalciových kanálů v léčbě hypertenze. Interní med pro praxi 2003; 5(9): 466–470.
10. Vítovec J, Špinar J, Špinarová L et al. Farmakoterapie kardiovaskulárních onemocnění. 3. vyd. Grada: Praha 2017. ISBN 978–80–247–4713–2.
11. Thomopoulos C, Parati G, Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension. 8. Outcome reductions versus discontinuations because of adverse drug events – meta-analyses of randomized trials. J Hypertens 2016; 34(8):1451–1463. Dostupné z DOI: <http://dx.doi.org/10.1097/HJH.0000000000000972>.
12. Thomopoulos C, Parati G, Zanchetti A. Effects of blood-pressure-lowering treatment in hypertension: 9. Discontinuations for adverse events attributed to different classes of antihypertensive drugs: meta-analyses of randomized trials. J Hypertens 2016; 34(10): 1921–1932. Dostupné z DOI: <http://dx.doi.org/10.1097/HJH.0000000000001052>.
Labels
Angiology Diabetology Internal medicine Cardiology General practitioner for adultsArticle was published in
Athero Review
2018 Issue 1
Most read in this issue
- Secondary and adverse effects of antihypertensive drugs
- Fats in foods from health point of view
- Peripheral arterial disease of lower extremity and global cardiovascular risk
- Diabetes mellitus and heart failure: the role of SGLT2 inhibitors