Measuring lipoprotein(a) concentrations: what and how do we measure and where do we go from here?

Česká verze

Authors: Vladimír Soška ^1,2; Ondřej Kyselák ^1,3
Authors place of work: Oddělení klinické biochemie FN U sv. Anny v Brně ¹; II. interní klinika LF MU a FN U sv. Anny v Brně ²; Katedra laboratorních metod LF MU, Brno ³
Published in the journal: AtheroRev 2023; 8(3): 172-176
Category: Přehledové práce

Summary

Lipoprotein(a) is an atypical lipoprotein whose level in the blood is genetically determined. According to current knowledge, it is an independent risk factor for atherosclerotic cardiovascular disease and for aortic valvular stenosis. Currently, there is no specific therapy available to reduce its blood concentration, but RNA-interference-based therapy is in advanced clinical trials. The management of patients with high Lp(a) levels will require that a reliable method of measuring its concentration in the blood is available. Currently used methods that measure Lp(a) concentration in mass units cannot be reliable, mainly because of the very high variability of the Lp(a) particle. To improve the quality of diagnosis, standardization of measurements with a transition to measuring the molar concentration of Lp(a) and with a follow-up to a suitable international standard is necessary.

Keywords:

apolipoprotein(a) – LDL-cholesterol – lipoprotein(a) – measurement standardization

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