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Additional Cardiovascular Risk in Patients Living with HIV Associated with Antiretroviral Therapy

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Autoři: Bashir M. Maelin;  Pavel Kraml
Působiště autorů: Interní klinika 3. LF UK a FN Královské Vinohrady, Praha
Vyšlo v časopise: AtheroRev 2023; 8(3): 185-192
Kategorie: Přehledové práce

Souhrn

HIV/AIDS je jedním z největších celosvětových zdravotních problémů. Ke snížení rizika dlouhodobých komplikací a prodloužení přežití vyžaduje infekce HIV/AIDS nepřetržitou lékařskou péči s kombinovanou antiretrovirovou léčbou a edukací pacientů v oblasti self-managementu. Nedávné epidemiologické údaje jasně prokázaly, že prevalence KVO u osob žijících s HIV celosvětově stoupá a u těchto osob je považována za nejčastější příčinu kardiovaskulární morbidity a mortality. Navzdory terapeutickým přínosům uvedeným v tomto přehledovém článku je dlouhodobá expozice antiretrovirové léčbě spojena s metabolickými komplikacemi, jako je lipodystrofie, inzulinová rezistence, centrální adipozita, přírůstek hmotnosti, plicní hypertenze a dyslipidemie vedoucí k předčasné manifestaci KVO.

Klíčová slova:

antiretrovirové léky – kardiovaskulární riziko – pacienti s HIV

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